Wikipedia
Mind the pot, Ope.
The Andy Griffith Show, “Quiet Sam” (S1E29 – Netflix)
Seemingly the earliest reference to cannabis in a streaming-available show comes in this 1961 episode of the apple pie series about a small-town sheriff (Griffith) and his spasmodic deputy Barney Fife (Don Knotts). No, Aunt Bea and Floyd the Barber don’t trade dabs while Opie and Andy are off at the ol’ fishing hole. Instead, the plot revolves around Barney harassing a quiet, shifty-eyed loner for no good reason (ah, police abuse of powers … always good for a wholesome chuckle), suspecting the guy of growing marijuana when he sees him tilling the fields at night.